Synthesis of α-fluoro-β-hydroxy alkylsulfanyl esters via a nucleophilic fluorination of sulfides

DOI: 10.1016/S0040-4020(98)00639-5

Source and publish data:

Tetrahedron p. 10801 - 10810 (1998)

Update date:2022-07-29

Topics:

Authors:

Jouen Jouen

Lemaitre

Lequeux Lequeux

Pommelet

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Article abstract of DOI:10.1016/S0040-4020(98)00639-5

By halogen-exchange reaction using NEt₃-3HF as fluoride source, methyl 2-fluoro-2-alkylsulfanyl acetate 3a-d could be obtained in good yields. Their ester enolates reacted with aromatic or aliphatic aldehydes, to lead to methyl α-atkylsulfanyl-

Full text of DOI:10.1016/S0040-4020(98)00639-5

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Product name:methyl 2-benzylsulfanyl-2-fluoroacetate

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