Bioorganic and Medicinal Chemistry Letters p. 833 - 838 (1996)
Update date:2022-08-03
Topics:
Clitherow
Beswick
Irving
Scopes
Barnes
Clapham
Brown
Evans
Hayes
Replacement of the isothiourea moiety of known histamine H3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H3 antagonist.
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