A general approach to the enantiomeric synthesis of lipidic α-amino acids, peptides and vicinal amino alcohols

Article abstract of DOI:10.1016/0957-4166(96)00084-5

A general methodology for the synthesis of saturated lipidic amino acids based on the oxidative cleavage of amino diols obtained by the regioselective opening of enantiomerically enriched 2,3-epoxy alcohols is described. The method opens the way to the synthesis of the enantiomers of lipidic 2-amino alcohols and homo- and hetero-peptides.