Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist

DOI: 10.1016/S0968-0896(96)00253-2

Source and publish data:

Bioorganic and Medicinal Chemistry p. 415 - 427 (1997)

Update date:2022-08-03

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Authors:

Tvaermose-Nielsen, Ole

Rachlin, Schneur

Dannacher, Heinz

Bjoerkling, Fredrik

Kirstein, Dorte

Bramm, Erik

Kaergaard Nielsen, Christian

Mortensen, Jens Thing

Binderup, Lise

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Article abstract of DOI:10.1016/S0968-0896(96)00253-2

The present paper describes the structural modifications leading to the discovery of a new series of quinoline-containing cys-LT₁ receptor (LTD₄ receptor) antagonists. A structural optimization with respect to the in vitro receptor b

Full text of DOI:10.1016/S0968-0896(96)00253-2

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