A selective intramolecular aldol condensation directed by a bifunctional enzyme mimic

Article abstract of DOI:10.1016/0040-4039(96)00337-1

The intramolecular aldol condensation of a dialdehyde carrying a t-butylphenyl group is almost random with simple imidazole buffer catalysis, but shows a 97% preference for a single regiochemistry of cyclization when the reaction is catalyzed by the imida