Bioorganic and Medicinal Chemistry Letters p. 2003 - 2008 (1997)
Update date:2022-08-05
Topics:
Marder, Mariel
Zinczuk, Juan
Colombo, Maria I.
Wasowski, Cristina
Viola, Haydee
Wolfman, Claudia
Medina, Jorge H.
Ruveda, Edmundo A.
Paladini, Alejandro C.
A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already described, indicates that substitutions at position 6 or 6 and 3' in the flavone nucleus are the only ones that give rise to high affinity BDZ-R ligands.
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