Synthesis of novel C2 symmetrical and enantiomerically pure thiepines

Article abstract of DOI:10.1016/S0040-4039(98)02460-5

Novel thiepines were synthesised using a Sharpless asymmetric dihydroxylation reaction to introduce the two chiral centres and with ring closure achieved by using sulfur diimidazole in conjunction with either a double ortho-lithiation or a double bromine/