The Influence of Protecting Groups on the β-Sheet-Structure Stability of Protected Peptides

Article abstract of DOI:10.1246/bcsj.69.1303

The influence of protecting groups on the β-sheet-structure stability of protected peptides was studied in organic solvents. α-Amino groups, carboxyl groups, and side-chain functional groups of model peptides were protected by availably used protecting groups. The difference between the solubilities of model peptides was investigated by the solvent-titration method using infrared (IR) absorption spectra. The β-sheet-structure-stabilizing potentials (SPβ) of each protecting group showed similar behaviors, except for Npys, Mts, and Z₂. The result exhibits that the values of the protected peptide are almost independent of the kinds of their protecting group.