Bulletin of the Chemical Society of Japan p. 1303 - 1307 (1996)
Update date:2022-08-05
Topics:
Oh-uchi, Sho-Kichi
Lee, Jin-Shik
Narita, Mitsuaki
The influence of protecting groups on the β-sheet-structure stability of protected peptides was studied in organic solvents. α-Amino groups, carboxyl groups, and side-chain functional groups of model peptides were protected by availably used protecting groups. The difference between the solubilities of model peptides was investigated by the solvent-titration method using infrared (IR) absorption spectra. The β-sheet-structure-stabilizing potentials (SPβ) of each protecting group showed similar behaviors, except for Npys, Mts, and Z2. The result exhibits that the
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