Tetrahedron p. 12821 - 12830 (1996)
Update date:2022-08-05
Topics:
Nemeth, Gabor
Kapiller-Dezsofi, Rita
Lax, Gyoergyi
Simig, Gyula
Highly stereoselective eliminations were achieved by acid-catalysed dehydration of 1-(4-alkoxy)-3,3,3-trifluoro-1,2-diphenylpropan-1-ols (10, 11, 15). The influence of the trifluoromethyl group on the stereochemistry of the elimination has been discussed. The observed high stereoselectivity has been applied to give a new, practical synthesis of antiestrogenic drug panomifene (1).
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(1996)