
Journal of Medicinal Chemistry p. 3400 - 3407 (1994)
Update date:2022-09-26
Topics:
Li, Leping
Wang, Hui-Kang
Kuo, Sheng-Chu
Wu, Tian-Shung
Mauger, Anthony
et al.
A series of 3',6,7-substituted 2-phenyl-4-quinolones were designed and synthesized as antimitotic antitumor agents. All compounds showed cytotoxic effects (log GI50=-4.0; log drug molar concentration required to cause 50percent inhibition) against the growth of a variety of human tumor cell lines, including those derived from solid tumors such as non-small cell lung, colon, central nervous system, ovary, prostate, and breast cancers, when evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. The most potent compound (26) demonstrated strong cytotoxic effects with GI50 values in the nanomolar or subnanomolar range in almost all the tumor cell lines. Compound 26 was also a potent inhibitor of tubulin polymerization and radiolabeled colchicine binding to tubulin, with activity comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.
View MoreSHANDONG CREDAGRI CHEMICAL CO., LTD.
Contact:+86-531-88872050
Address:ROOM 601A, BUILDING 2, SHUNTAI SQUARE, NO. 2000 SHUNHUA ROAD, HI-TECH DEVELOPMENT ZONE, JINAN, CHINA.
Contact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
taicang liyuan chemical co,.ltd
website:http://www.tcliyuanchem.com/productse.php
Contact:86-512-53539583
Address:Room 804,Huaxu Building,No.95,Renmin South Road,Taicang city,Jiangsu Province,China
Contact:+86-532-80762375
Address:No. 6, Hongkong Middle Road, Qingdao, China
SICHUAN ZHONGBANG NEW MATERIAL CO., LTD
website:http://www.zhongbangst.com
Contact:86-830-2585019
Address:sichuan,china
Doi:10.1016/0008-6215(96)00039-0
(1996)Doi:10.1007/BF00481584
()Doi:10.1002/hlca.19960790302
(1996)Doi:10.1021/om960284p
(1996)Doi:10.3987/COM-93-6391
(1993)Doi:10.1016/0040-4039(96)00847-7
(1996)