
Journal of Medicinal Chemistry p. 3400 - 3407 (1994)
Update date:2022-09-26
Topics:
Li, Leping
Wang, Hui-Kang
Kuo, Sheng-Chu
Wu, Tian-Shung
Mauger, Anthony
et al.
A series of 3',6,7-substituted 2-phenyl-4-quinolones were designed and synthesized as antimitotic antitumor agents. All compounds showed cytotoxic effects (log GI50=-4.0; log drug molar concentration required to cause 50percent inhibition) against the growth of a variety of human tumor cell lines, including those derived from solid tumors such as non-small cell lung, colon, central nervous system, ovary, prostate, and breast cancers, when evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. The most potent compound (26) demonstrated strong cytotoxic effects with GI50 values in the nanomolar or subnanomolar range in almost all the tumor cell lines. Compound 26 was also a potent inhibitor of tubulin polymerization and radiolabeled colchicine binding to tubulin, with activity comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.
View MoreYangzhou Zhongbao Pharmaceutical Co.,Ltd
Contact:+86-514-88290838
Address:Jiangsu Baoying county economic develpment zone in baoying avenue91
Xi’an Gaoyuan Bio-Chem Co.,Ltd.
Contact:+86-29-65692259
Address:R11702, Block B, Greenland Soho, 1st Zhangba Rd, Xi'an Hi-tech Zone, Xi'an, Shaanxi, China. 710065
RongCheng Tianyu Technology Co.,Ltd.
Contact:86-631-7519595
Address:220Ping Donghai Road RongChengCity,ShangDong Province China
Taixing Shenfeng Chemical Co., Ltd.
Contact:+86-523-87117033, 87117666
Address:4# Yinsanlu, Huangqiao town, Taixing, Jiangsu, China.
Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.
Contact:--
Address:Huadian Pioneer Park, Huadian Township, Qihe County, Dezhou City, Shandong, P.R.China
Doi:10.1016/0008-6215(96)00039-0
(1996)Doi:10.1007/BF00481584
()Doi:10.1002/hlca.19960790302
(1996)Doi:10.1021/om960284p
(1996)Doi:10.3987/COM-93-6391
(1993)Doi:10.1016/0040-4039(96)00847-7
(1996)