Microbial reduction of α,α,α-trifluoro-α′-sulfenylketones

Article abstract of DOI:10.1016/0040-4039(96)00685-5

Several microorganisms have been employed in the reduction of two α,α,α-trifluoro-α′-sulfenylketones. Some of them produce corresponding alcohols in high diastero-and enantioselection, the high conversion in a single enantiomer being secured by the racemization of starting ketones in the biotransformation conditions. Transformation of obtained sulfenyl-trifluoromethyl-alcohols into trifluoromethyl-epoxides is also described. Copyright