Unexpected diastereoselectivity in the formation of 3,5-disubstituted indolizidines by intramolecular reductive amination

Article abstract of DOI:10.1016/0957-4166(96)00187-5

The reductive amination of appropriate ketopyrrolidines leading to 3,5- dialkylindolizidines usually gives stereoselectively the indolizidine with a cis relative stereochemistry on the piperidine moiety We report herein unexpected results concerning the e