Synthesis of 2,6-anhydro-3-deoxy-5-O-phosphono-3-tetradecanamido-4-O-[(R)-3-(tetrad ecanoyloxy)tetradecanoyl]-D-glycero-D-ido-heptonic acid as a new potent endotoxin antagonist and its dimeric analogue

DOI: 10.1016/0040-4039(96)01646-2

Source and publish data:

Tetrahedron Letters p. 7271 - 7274 (1996)

Update date:2022-08-03

Topics:

Authors:

Shiozaki, Masao

Mochizuki, Takashi

Wakabayashi, Takanori

Kurakata, Shin-Ichi

Tatsuta, Tohru

Nishijima, Masahiro

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Article abstract of DOI:10.1016/0040-4039(96)01646-2

A pyran carboxylic acid analogue of GLA-60 (14) and its dimeric analogue 18 were synthesized in a stereocontrolled manner. Compound 14 showed strong LPS-antagonistic activity.

Full text of DOI:10.1016/0040-4039(96)01646-2

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