Reaction of acyl isothiocyanates with nucleophiles: A convenient synthesis of 1,3-oxazine, pyrimidinethione and thiazole derivatives

Article abstract of DOI:10.1080/10426509608029633

The reaction of acetyl isothiocyanate 1 with ethyl cyanoacetate, malononitrile and/or a cyclic β-diketone afforded the corresponding 1,3-oxazines 3, 11 and thioamide 12 respectively. The heteroannulation of 3 and the synthesis of thiazole 18 is described.

Full text of DOI:10.1080/10426509608029633

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Phosphorus, Sulfur, and Silicon and
the Related Elements
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REACTION OF ACYL
ISOTHIOCYANATES WITH
NUCLEOPHILES: A CONVENIENT
SYNTHESIS OF 1,3-OXAZINE,
PYRIMIDINETHIONE AND THIAZOLE
DERIVATIVES
M. G. Assy a
a Chemistry Department, Faculty of Science, Zagazig
University, Zagazig, Egypt
Version of record first published: 24 Sep 2006.
To cite this article: M. G. Assy (1996): REACTION OF ACYL ISOTHIOCYANATES WITH
NUCLEOPHILES: A CONVENIENT SYNTHESIS OF 1,3-OXAZINE, PYRIMIDINETHIONE AND THIAZOLE
DERIVATIVES, Phosphorus, Sulfur, and Silicon and the Related Elements, 108:1-4, 15-20
To link to this article: http://dx.doi.org/10.1080/10426509608029633
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