Bulletin of the Chemical Society of Japan p. 2715 - 2720 (1998)
Update date:2022-08-03
Topics:
Toyota, Shinji
Yasutomi, Akihiro
Kojima, Hiroharu
Igarashi, Yuko
Asakura, Mitsuhiro
Oki, Michinori
The title compound was prepared by addition of 4,5-dimethoxybenzyne to 9,9'-bianthryl. The rotational isomers, ap and ±sc, were separated by HPLC. The ±sc isomers were treated with sodium ethanethiolate to produce 3,3'- dihydroxy-2,2'-dimethoxy-9,9'-bitriptycyl, which was converted to the ester of ('S, 5R,7R)-4-[(2-carboxy)benzoyl]-3-thia-4- azatricyclo[5.2.1.01,5]decane 3,3-dioxide. The resulting diastereomers were separated by HPLC. The isomers were hydrolyzed and methylated with dimethyl sulfate to yield optically active 2,2',3,3'-tetramethoxy-9,9'- bitriptycyl. The absolute conformation of the tetramethoxy compound was determined by X-ray structure analysis of 3'-ester of (1S,5R, 7R)-4-(2- carboxybenzoyl)-3-thia-4-azatricyclo[5.2.1.01,5]decane 3,3-dioxide derived from 3-hydroxy-2,2',3'-trimethoxy-9,9'-bitriptycyl, followed by hydrolysis and then methylation. The CD spectrum of Msc-2,2',3,3'-tetramethoxy-9,9'- bitriptycyl is reported.
View MoreShandong Xinhua Pharmaceutical Co.,Ltd
website:http://www.xhzy.com
Contact:+86-533-2196801
Address:1 lutai road,zhangdian dis,Zibo City
Suzhou Kangrun Pharmaceutical, Inc
Contact:86-512-63912376,63913329
Address:Building 2, No. 2358 ,Chang'an Rd, Wujiang Economic Development Zone Pioneering park, china
website:http://www.hybio.com.cn
Contact:+86 755 26588093
Address:No.9 Linkong West Street, Hengdian Street, Huangpi District, Wuhan City, China.
jintan yufan Medicine Raw materials Co.,Ltd.(expird)
Contact:86-519-82808282
Address:6th,Jincheng Huangzhuang
Shenyang Xinyihan Chemical Technology Co., Ltd.
Contact:+86-18525026267
Address:362, aigongbeijei street 23 , tiexi district,Shenyang, Liaoning, China
Doi:10.1002/jhet.5570330336
(1996)Doi:10.1039/d0dt03414b
(2020)Doi:10.1016/0040-4039(96)00874-X
(1996)Doi:10.1039/b201304e
(2002)Doi:10.1039/jr9570000137
(1957)Doi:10.1016/j.tetlet.2012.07.115
(2012)