Asymmetric synthesis of the Abbott amino dihydroxyethylene dipeptide isostere subunit

Article abstract of DOI:10.1016/0040-4039(96)00874-X

The aminodiol 1b, a N-benzyl protected form of the Abbott dipeptide isostere 1a is prepared, starting from an appropriate α,β-unsaturated ester, involving an asymmetric dihydroxylation and a rearrangement of an intermediate anti α,β-aminoepoxide.