Synthesis and structure-activity relationship of trimebutine derivatives

DOI: 10.1248/cpb.44.1168

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1168 - 1173 (1996)

Update date:2022-08-02

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Authors:

Sai, Hiroshi

Ozaki, Yasuhiko

Hayashi, Kimiaki

Onoda, Yuichi

Yamada, Kenji

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Article abstract of DOI:10.1248/cpb.44.1168

Trimebutine derivatives were synthesized by utilizing alkylation or acylation of isonitriles and nitrile as a key step. The colonic contractile effects of these compounds were examined, and T-1815 was found to have strong colonic propulsive activity.

Full text of DOI:10.1248/cpb.44.1168

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