A new route to aminodiazines via metalation reaction. Synthesis of an aza analogue of Nevirapine: Diazines XV

Article abstract of DOI:10.1055/s-1996-4303

A new route to aminodiazines is reported, the ortho-directed lithiation of diazines is used, followed by reaction with tosyl azide as an electrophile. The reduction of the azido or tetrazolo compounds obtained was achieved and led to the expected amines. This methodology has allowed the synthesis of new aminodiazines and an improvement in the yield of various aminodiazines previously described. This reaction was used for the preparation of an aza analogue of Nevirapine.