Synthetic Communications p. 2092 - 2098 (2015)
Update date:2022-08-03
Topics:
Sundaram, Dhanraj T. S. S.
Mitra, Jayati
Rajesh
Islam, Aminul
Prabahar, Koilpillai Joseph
Rao, Battula Venkateswara
Douglas, Sanasi Paul
This report describes a synthesis of two potent impurities of repaglinide, benzyl repaglinide 1 and repaglinide isomer 2, from commercially available raw materials: 2-fluoro benzonitrile, (S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butylamine (5), and 3-ethoxy-[4-(ethoxycarbonyl)phenyl]acetic acid (7). These impurities are the crucial components in determining the quality of the drug substance, repaglinide, during its manufacturing.
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