Synthesis and highly diastereoselective alkylation of chiral N-[(S,S)-3,5-bis(1-methoxyethyl)-1,2,4-triazol-4-yl]arylimines

Article abstract of DOI:10.1016/0957-4166(96)00196-6

(S,S)-4-Amino-3,5-bis(1-hydroxyethyl)-1,2,4-triazole 2 (SAT) (from (S)-lactic acid and hydrazine hydrate) reacted with substituted benzaldehydes 6 to afford N-[(S,S)-3,5-bis(1-hydroxyethyl)-1,2,4-triazol-4-yl]arylimines 3 in excellent yield. Protection of