Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase

DOI: 10.1016/S0960-894X(99)00323-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1991 - 1996 (1999)

Update date:2022-08-03

Topics:

Authors:

Ciccarone, Terrence M.

MacTough, Suzanne C.

Williams, Theresa M.

Dinsmore, Christopher J.

O'Neill, Timothy J.

Shah, Daksha

Culberson, J. Christopher

Koblan, Kenneth S.

Kohl, Nancy E.

Gibbs, Jackson B.

Oliff, Allen I.

Graham, Samuel L.

Hartman, George D.

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Article abstract of DOI:10.1016/S0960-894X(99)00323-6

The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Substitutions on an imidazolylmethyl-AMBA- methionine template gave a highly potent and cell-active inhibitor.

Full text of DOI:10.1016/S0960-894X(99)00323-6

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