Identification and structure-activity relationship studies of osthol, a cytotoxic principle from Cnidium monnieri

DOI: 10.1016/0960-894X(96)00315-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1791 - 1794 (1996)

Update date:2022-08-04

Topics:

Authors:

Hitotsuyanagi, Yukio

Kojima, Hiroshi

Ikuta, Hiroshi

Takeya, Koichi

Itokawa, Hideji

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00315-0

Osthol (1) was isolated from the fruit of Cnidium monnieri as a cytotoxic principle. Its structure-activity relationship study reveals that the 3,4-olefinic bond is essential for its cytotoxic activity, and the prenyl (C₅) unit attached at the 8 position enhances the cytotoxicity. Analogues 7 and 8 that have a longer alkoxy unit at the 7 position showed ten times higher cytotoxicity than 1.

Full text of DOI:10.1016/0960-894X(96)00315-0

Products guided by the article

Product name:8-isopentyl-7-methoxy-chroman-2-one

Cas No:181303-71-9

R&D Labs maybe for 181303-71-9

Second Pharma Co., Ltd

Contact:+86-575-82733999 0575-82732999

Address:hangzhou gulf fine chemical zone,shangyu city,zhejiang province
Li's chemicals

Contact:+86-15850770348

Address:51 OF XIANGFANGCUN ROAD, Nanjing 210002, China
Chongqing Yawei Fine Chemical Co.,Ltd

Contact:0086-23-62849407

Address:Ziyou village, Nanquan town, Banan district, Chongqing China
Shanghai Pengkai Chemical Co.,Ltd

Contact:+86-21-60526671

Address:No.4226 Duzhuang Rd Minhang District Shanghai China
SuZhou Hua-Emy Chemical Import and Export Co., LTD.

Contact:+86-512-88804994; +86-512-88804550;

Address:710, Building B, International Trade Center, 12 Huanghelu, Changshu, Jiangsu,China

Relevant to this article

Organoiron selenium complexes. Synthesis and characterization of tert-butyl substituted cyclopentadienyldicarbonylselenocarboxylate iron complexes, Cp′Fe(CO)₂SeCOR (Cp′ = C₅H₅, t-BuC₅H₄, 1,3-t-Bu

Doi:10.1080/00945719608005133
(1996)
Homogeneous hydrogenation with new cationic ruthenium(II) complexes of [RuH(CO)(NCCH₃)(PPh₃)₂(diphos)]⁺ and [RuH(CO)(NCCH₃)(PPh₃)(diphos)]⁺. Crystal structure of [RuH(CO)(NCCH₃)(PPh₃) (Fe(η⁵-C₅H₄PPh₂) ₂)][BF₄]

Doi:10.1016/0277-5387(96)00103-9
(1996)
Reactions of (σ-alkynyl)platinum complexes with [Pd(η³-C₃H₅)Cl]₂. Synthesis of bis(η²-alkyne)(η³-allyl)palladiuin(II) complexes. Crystal and molecular structure

Doi:10.1021/om9603326
(1996)
Synthesis and electrospray mass spectrometry of platinum(ii) complexes derived from thiourea dianions and the x-ray structure of [pt{nmec(=ncn)s}(cod)] (cod = cyclo-octa-1,5-diene)

Doi:10.1016/0277-5387(96)00133-7
(1996)
Inner sphere complexes derived from the coordinate interactions of tin(IV) isothiocyanate moieties with 1-[(4-methylphenylimino)methyl]-2-phenol. Crystal structure of diisothiocyanatodimethylbis〈1-[(4-methylphenylimino)methyl]-2- phenol〉tin(IV), me₂sn(ncs)₂ · [hoc₆h₄ch:Nc₆h₄ch₃] ₂

Doi:10.1016/0277-5387(96)00147-7
(1996)
Convenient Synthesis of Functionalized Dialkyl Ketones and Alkanoylsilanes: 1-(Benzotriazol-1-yl)-1-phenoxyalkanes as Alkanoyl Anion Equivalents

Doi:10.1021/jo960830o
(1996)

Article Doi