Identification and structure-activity relationship studies of osthol, a cytotoxic principle from Cnidium monnieri

DOI: 10.1016/0960-894X(96)00315-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1791 - 1794 (1996)

Update date:2022-08-04

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Authors:

Hitotsuyanagi, Yukio

Kojima, Hiroshi

Ikuta, Hiroshi

Takeya, Koichi

Itokawa, Hideji

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Article abstract of DOI:10.1016/0960-894X(96)00315-0

Osthol (1) was isolated from the fruit of Cnidium monnieri as a cytotoxic principle. Its structure-activity relationship study reveals that the 3,4-olefinic bond is essential for its cytotoxic activity, and the prenyl (C₅) unit attached at the 8 position enhances the cytotoxicity. Analogues 7 and 8 that have a longer alkoxy unit at the 7 position showed ten times higher cytotoxicity than 1.

Full text of DOI:10.1016/0960-894X(96)00315-0

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