The synthesis of thrombin inhibitor L-370,518 via an α-hydroxy-β- lactam

DOI: 10.1016/0040-4039(96)01013-1

Source and publish data:

Tetrahedron Letters p. 5045 - 5048 (1996)

Update date:2022-08-03

Topics:

Authors:

Cutrona, Kellie J.

Sanderson, Philip E. J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(96)01013-1

We describe an efficient synthesis of thrombin inhibitor L-370,618 (1) via β-lactam 2. The synthesis of 2 is carried out in six steps from 4- aminocyclohexane carboxylic acid, with a yield of 27%.

Full text of DOI:10.1016/0040-4039(96)01013-1

Products guided by the article

Product name:{4-[(E)-Benzylimino-methyl]-cyclohexyl}-carbamic acid tert-butyl ester

Cas No:181308-53-2

R&D Labs maybe for 181308-53-2

Penglai Qianwei Chemical Co., Ltd.

Contact:86-535-3357802

Address:Shahelu (north), Penglai, Shandong, China
Changzhou Screw International Trading Co., Ltd.

Contact:13906149256,18001495888

Address:Jiangsu，Jintanqu
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.

Contact:+86-512-6585 6968

Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Qingdao Pana-Life Biochem Co.,Ltd.

Contact:86-532-87683902

Address:No.967 Dalao Road, Licang Zone, Qingdao City,Shandong, China 266021
Angelisun(Chongqing) Pharmaceutical Co., LTD.

Contact:+86-23-68030926-816

Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China

Relevant to this article

Oxidative organophotoredox catalysis: A regioselective synthesis of 2-nitro substituted imidazopyridines and 3-substituted indoles, initiated by visible light

Doi:10.1039/c6nj02365g
(2016)
Reactions of tertiary propargyl alcohols with sodium halides under oxidative conditions

Doi:10.1016/j.tetlet.2014.02.042
(2014)
A Bis(2,6-di-tert-butyl-4-methylphenolato)samarium(II) Complex, .thf

Doi:10.1107/S0108270193014234
(1994)
Phenyl derivative of iron 5,10,15-tritolylcorrole

Doi:10.1021/ic5003572
(2014)
A Highly Efficient Diversification of 2-Amino/Amido-1,3,4-oxadiazole and 1,3,4-Thiadiazole Derivatives via Reagent-Based Cyclization of Thiosemicarbazide Intermediate on Solid-Phase

Doi:10.1021/acscombsci.5b00140
(2015)
The chemistry of 2H-3,1-benzoxazine-2,4(1H)-dione (isatoic anhydride). 19. Direct formation of 2-aminobenzyl alcohols from the reduction of N-substituted isatoic anhydrides

Doi:10.1002/jhet.5570230145
(1986)

Article Doi