The synthesis of thrombin inhibitor L-370,518 via an α-hydroxy-β- lactam

DOI: 10.1016/0040-4039(96)01013-1

Source and publish data:

Tetrahedron Letters p. 5045 - 5048 (1996)

Update date:2022-08-03

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Authors:

Cutrona, Kellie J.

Sanderson, Philip E. J.

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Article abstract of DOI:10.1016/0040-4039(96)01013-1

We describe an efficient synthesis of thrombin inhibitor L-370,618 (1) via β-lactam 2. The synthesis of 2 is carried out in six steps from 4- aminocyclohexane carboxylic acid, with a yield of 27%.

Full text of DOI:10.1016/0040-4039(96)01013-1

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