Tetrahedron Letters p. 5045 - 5048 (1996)
Update date:2022-08-03
Topics:
Cutrona, Kellie J.
Sanderson, Philip E. J.
We describe an efficient synthesis of thrombin inhibitor L-370,618 (1) via β-lactam 2. The synthesis of 2 is carried out in six steps from 4- aminocyclohexane carboxylic acid, with a yield of 27%.
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