Synthesis of quaternary amino acids containing β,γ- and well as γ,δ-unsaturated side chains via chelate-enolate Claisen rearrangement

Article abstract of DOI:10.1016/0040-4039(96)01104-5

Ester enolate Claisen rearrangement of chelated N-protected α,β-unsaturated amino acid allylic esters results in a migration of the double bond and the formation of highly unsaturated amino acids in good yields and in a highly diastereoselective fashion.