Bioorganic and Medicinal Chemistry Letters p. 1589 - 1594 (1996)
Update date:2022-07-29
Topics:
Rasetti, Vittorio
Cohen, N. Claude
Rueeger, Heinrich
Goeschke, Richard
Maibaum, Juergen
Cumin, Frederic
Fuhrer, Walter
Wood, Jeanette M.
The design and synthesis of new truncated δ-amino hydroxyethylene dipeptide isosteres lacking the P4-P2 peptide backbone is described. The most active compounds 15c and 30c inhibited human renin in the submicromolar range. This promising concept may offer the possibility to discover completely non-peptide, low-molecular weight renin inhibitors with improved pharmacokinetic properties.
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