Copper catalyzed Grignard cross-coupling reaction with β-perfluoroalkyl-substituted alkyl halides

Article abstract of DOI:10.1016/0040-4039(96)01155-0

Coupling reaction of β-perfluoroalkyl-substituted alkyl halides with Grignard reagents such as phenyl-, vinyl-, allyl-, benzyl-, and alkyl-magnesium halides was catalyzed by copper salts or complexes to give the corresponding cross-coupling products in good yields. α,ω-Diiodoalkane bearing a polyfluoroalkylene moiety also reacted with 2 equiv. of Grignard reagent in the presence of copper catalyst to given α,ω-bi-functionalized product.