The preparation of 1H-pyrazole-1-carboxylic acid, 1,1-dimethylethyl esters from dilithiated C(α),N-hydrazones of hydrazinecarboxylic acid, 1,1-dimethylethyl ester

DOI: 10.1080/00397919608003780

Source and publish data:

Synthetic Communications p. 3659 - 3669 (1996)

Update date:2022-07-29

Topics:

Authors:

Church, A. Cameron

Koller, Madlene U.

Hines, Margaret A.

Beam, Charles F.

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Article abstract of DOI:10.1080/00397919608003780

C(α),N-Hydrazones of hydrazinecarboxylic acid, 1,1-dimethylethyl ester [C(α),N-carbo-t-butoxyhydrazones] were metalated with excess lithium diisopropylamide, and the dianion-type intermediates were condensed with select aromatic esters followed by acid cyclization to substituted 1H-pyrazole-1-carboxylic acid, 1,1-dimethylethyl esters (N-carbo-t-butoxypyrazoles).

Full text of DOI:10.1080/00397919608003780

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