Synthesis and evaluation of trimetoquinol derivatives: Novel thromboxane A2/prostaglandin H2 antagonists with diminished β-adrenergic agonist activity

DOI: 10.1021/jm950896w

Source and publish data:

Journal of Medicinal Chemistry p. 85 - 91 (1997)

Update date:2022-07-29

Topics:

Authors:

Christoff, Jeffrey J.

Bradley, Luke

Miller, Duane D.

Lei, Longping

Rodriguez, Fernando

Fraundorfer, Paul

Romstedt, Karl

Shams, Gamal

Feller, Dennis R.

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Article abstract of DOI:10.1021/jm950896w

Trimetoquinol (TMQ, 1) is a unique catecholamine with a strong stereodependence for agonism at β-adrenergic (S >> R) and antagonism at thromboxane A₂/prostaglandin H₂ (TP; R >> S) receptors. Our laboratory has reported the effects of

Full text of DOI:10.1021/jm950896w

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