Total synthesis of phomactin D

DOI: 10.1016/0040-4039(96)01585-7

Source and publish data:

Tetrahedron Letters p. 7107 - 7110 (1996)

Update date:2022-08-05

Topics:

Authors:

Miyaoka, Hiroaki

Saka, Yasuhiro

Miura, Shotaro

Yamada, Yasuji

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Article abstract of DOI:10.1016/0040-4039(96)01585-7

The first total synthesis of PAF antagonist marine diterpenoid phomactin D was achieved from L-ascorbic acid. This synthesis involves the formation of bicyclo[2.2.2]octane derivative 3 by the sequential Michael reaction, oxidative cleavage of the double bond of 4 and cyclization of sulfone 18.

Full text of DOI:10.1016/0040-4039(96)01585-7

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