Asymmetric synthesis of enantiomerically pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): A potent and selective ligand at group II metabotropic glutamate receptors

DOI: 10.1016/0960-894X(96)00407-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2243 - 2246 (1996)

Update date:2022-08-05

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Authors:

Marinozzi, Maura

Natalini, Benedetto

Costantino, Gabriele

Tijskens, Pierre

Thomsen, Christian

Pellicciari, Roberto

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Article abstract of DOI:10.1016/0960-894X(96)00407-6

The enantioselective synthesis of (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine (PCCG-4, 3), a potent and selective mGluR2 antagonist is described.

Full text of DOI:10.1016/0960-894X(96)00407-6

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