Journal of Antibiotics p. 900 - 908 (1996)
Update date:2022-08-02
Topics:
Tsuda, Makoto
Muraoka, Yasuhiko
Someno, Tetsuya
Nagai, Machiko
Aoyagi, Takaaki
Takeuchi, Tomio
Several pyrrolidine-containing analogues of poststatin were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Replacement of the postine residue with 2-oxo-2-(2-pyrrolidinyl)acetic acid increased the selectivity and inhibitory activity against prolyl endopeptidase. Benzyloxycarbonyl-L-phenylalanyl-(S)-2-oxo-2-(2-pyrrolidinyl)acetyl -D-phenylalanine was about 46 times as active to prolyl endopeptidase as natural poststatin.
View Morewebsite:http://www.amadischem.com
Contact:86-571-89925085
Address:Watts Cosine.No.166.Xiangmao Road.
Chengdu ZY Biochemical Technology Co., LTD
Contact:0086-28-88680086
Address:170 Qingpu Road, Shouan Town, Pujiang County
Contact:+86-0760-85282375
Address:zhongjing road,zhongshan torch hi-tech industrial development zone
KAIYUAN CHEMICAL COMPANY LIMITED.
website:http://www.kaiyuanchem.com
Contact:+86-22-59891255/66/77
Address:B-2205, Kuangshi International Building, Yingbin Road, XiangLuo Bay Business District, Binhai New area, Tianjin, China.
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Doi:10.1016/0957-4166(96)00365-5
(1996)Doi:10.1016/S0277-5387(00)88018-3
(1984)Doi:10.1002/jlac.199619961117
(1996)Doi:10.1139/v75-005
(1975)Doi:10.1016/S0022-1139(96)03490-2
(1996)Doi:10.1021/ja993604f
(2000)