Enantiospecific synthesis of 8-O-methylthioswainsonine from a derivative of D-glucose

Article abstract of DOI:10.1016/0957-4166(96)00330-8

The thioanalogue 1, (1R,2S,4S,8R,8aS)-1,2,8-trihydroxy-8-O-methylthioindolizidine of 8-O-methylswainsonine 2 has been enantiospecifically synthesized from the important key intermediate methyl 2-O-methyl-3,6-thioanhydro-α-D-mannopyranoside 7, in five step