Journal of the Chemical Society. Perkin transactions I p. 2091 - 2102 (1996)
Update date:2022-08-03
Topics:
Spivey, Alan C.
Capretta, Alfredo
Frampton, Christopher S.
Leeper, Finian J.
Battersby, Alan R.
A novel approach, involving X-ray analysis of a specifically designed racemate, in combination with correlations by circular dichroism, allows the absolute configuration of the spiro lactam 4 to be determined. The outcome is that the enantiomer of this lactam which strongly inhibits uroporphyrinogen III synthase (cosynthetase) has the R-configuration and the implications of this finding are briefly discussed.
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(1996)Doi:10.1080/07328309608005702
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(1996)
