Biosynthesis of porphyrins and related macrocycles. Part 45. Determination by a novel X-ray method of the absolute configuration of the spiro lactam which inhibits uroporphyrinogen III synthase (cosynthetase)

DOI: 10.1039/p19960002091

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 2091 - 2102 (1996)

Update date:2022-08-03

Topics:

Authors:

Spivey, Alan C.

Capretta, Alfredo

Frampton, Christopher S.

Leeper, Finian J.

Battersby, Alan R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/p19960002091

A novel approach, involving X-ray analysis of a specifically designed racemate, in combination with correlations by circular dichroism, allows the absolute configuration of the spiro lactam 4 to be determined. The outcome is that the enantiomer of this lactam which strongly inhibits uroporphyrinogen III synthase (cosynthetase) has the R-configuration and the implications of this finding are briefly discussed.

Full text of DOI:10.1039/p19960002091

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:(S)-3-[(3R,4R,5R)-4,5-((R)-Benzylidenedioxy)-2-oxotetrahydropyran-3-yloxycarbonylmethyl]-9-benzyloxycarbonyl-2,7-bis(2-methoxycarbonylethyl)-8-methoxycarbonylmethyl-4-methyl-4,5-dihydrodipyrrin-1(10H)-one

Cas No:183061-70-3

R&D Labs maybe for 183061-70-3

Shandong Yaroma Perfumery Co., Ltd.

Contact:+86- 531- 88024598

Address:7-702 Caizhi Central, 59 Gong Ye South Road, Jinan City,250101, P. R. China
Shanxi Sanwei Group Co.,Ltd

Contact:0086-357-6662688

Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan
Hebei Fulong Import & Export Co., Ltd.

Contact:86-311-87795661

Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China
QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.

Contact:+86 532 80861829

Address:No. 1, Yinchuan East Road, 266061, Qingdao, China

Relevant to this article

Phosphate prodrugs for amines utilizing a fast intramolecular hydroxy amide lactonization

Doi:10.1021/jo961477p
(1996)
Chemical synthesis of (3-SO₃Na)GlcNAβ1-3Fucβ1→OMe: The oligosaccharide involved in the cell aggregation of the sponge Microciona prolifera

Doi:10.1080/07328309608005702
(1996)
Synthesis and photophysics of dinuclear gold(I) thiolates of bis(diphenylphosphino)-alkyl- and -aryl-amines. Crystal structure of [Au₂{Ph₂PN(C₆H₁₁)PPh ₂}(SC₆H₄F-p)₂]

Doi:10.1039/dt9960004019
(1996)
Doi:10.1016/S0040-4020(01)92000-9
(1968)
Supermolecular chemistry, 62. Ligand and cosubstrate effects on the hydrolysis of phosphate esters and DNA with lanthanoids

Doi:10.1002/jlac.199619961109
(1996)
Reactions of vanadocene and its monochloride with p-toluenesulfonyl chloride

Doi:10.1007/BF01431622
(1996)

Article Doi