Asymmetric synthesis of α-hydroxy acids via β-lactams

Article abstract of DOI:10.1016/0957-4166(96)00352-7

A diastereoselective synthesis of β-lactams 5a-e and 6a-e has been achieved, via a Staudinger reaction using imines derived from (1S)-(+)-camphor-10-sulfonamide, in good yields. The major diastereomers 6a-e were isolated in pure form by crystallization. T