Journal of Medicinal Chemistry p. 79 - 82 (1980)
Update date:2022-08-05
Topics:
Paris
Garmaise
Cimon
Swett
Carter
Young
A series of 1,3-dialkanoyl-2-(2-methyl-4-oxo-1,3-benzodioxan-2-yl)glycerides ('cyclic aspirin triglycerides') was synthesized. They demonstrated essentially all the systemic antiinflammatory activity associated with aspirin in the carrageenin-induced rat paw edema test. Examination of the rat stomachs showed that the 1,3-didecanoyl derivative did not cause gastric lesions.
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