Tetrahedron Letters p. 6033 - 6036 (1994)
Update date:2022-08-02
Topics:
Boros, Livia G.
Corte, Bart De
Gimi, Rayomand H.
Welch, John T.
Wu, Yang
Handschumacher, Robert E.
Fluoroolefin dipeptide isosteres were synthesized applying the Peterson reaction as a novel method for fluoroolefination.The dipeptide isosteres were elaborated to provide the conformationally constrained analogs (1-(R), 1-(S) and 2-(R), 2-(S)) of the Suc-Ala-Gly-Pro-Phe-pNA tetrapeptide, a synthetic substrate of cyclophilin.
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