Asymmetric synthesis of β-hydroxy sulfones by reduction of chiral β-keto sulfones

Article abstract of DOI:10.1016/0957-4166(96)00310-2

Chiral β-keto sulfones 3 have been prepared from enantiomerically pure sulfinic acids 2 derived from (R)- and (S)-methylbenzylamine. Enantiospecific reduction of these ketosulfones 3 can be achieved using different hydrides affording β-hydroxy sulfones. O