Synthetic Communications p. 4081 - 4089 (1996)
Update date:2022-08-04
Topics:
Bunce
Childress
The title compound was prepared in 48% overall yield using a seven-step sequence. The synthesis involves stepwise construction of a 3-formyl-3,3-diphenylpropyl side chain from the double bond of 3-ethenyl-3-methylcyclohexanone followed by aldol ring closure. The approach represents a general strategy for the synthesis of a number of (±)-7,7-diaryl-3,4,4a,5,6,7-hexahydro-1-1(2H)-naphthalenones.
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Doi:10.1016/S0223-5234(97)87535-6
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