The synthesis of fluorine-containing pterins

Article abstract of DOI:10.1016/0040-4020(96)00782-X

The synthesis of some 7,7-difluoro-7,8-dihydropterins and pterins with fluoroalkyl substituents at the 6 or 7 positions from fluorine-containing aliphatic precursors and suitably substituted pyrimidines is described. The fluorine-containing pterins were found to be very insoluble and also stable to nucleophiles and bases in dilute aqueous solution.