Facile synthesis of lysophospholipids containing unsaturated fatty acid chains

Article abstract of DOI:10.1016/0040-4039(96)01802-3

The efficient synthesis of polyunsaturated phospholipids is challenging due to the sensitivity of the unsaturated moiety to the conditions employed in phosphate ester deprotection. We discuss here three independent methods that resolve this issue and enable the synthesis of a series of unsaturated lysophosphatidic acid mimics for the development of a more comprehensive understanding of the structure-activity relationship in this series.