Bioorganic and Medicinal Chemistry Letters p. 2077 - 2080 (1998)
Update date:2022-08-04
Topics:
Natchus, Michael G.
Cheng, Menyan
Wahl, Christopher T.
Pikul, Stanislaw
Almstead, Neil G.
Bradley, Rimma S.
Taiwo, Yetunde O.
Mieling, Glen E.
Michelle Dunaway
Snider, Catherine E.
McIver, John M.
Barnett, Bobby L.
McPhail, Sara J.
Anastasio, Melanie B.
De, Biswanath
A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety.
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