Interphylal product splicing: The first total syntheses of cephalostatin 1, the North hemisphere of ritterazine G, and the highly active hybrid analogue, ritterostatin G(N)1(N)1

Article abstract of DOI:10.1021/ja972160p

Convergent total syntheses of the extremely potent cell growth inhibitor cephalostatin 1 and two hybrid analogues, ritterostatins G(N)1(N) and G(N)1(s), have been achieved. Ritterostatin G(N)1(N) displays sub-nanomolar activity in the 60 cell line human t