New strategy for the synthesis of the taxane diterpenes: Formation of the BC-rings of taxol via a [5+2]-pyrylium ylide-alkene cyclization, ring expansion strategy

DOI: 10.1016/0040-4039(95)01083-T

Source and publish data:

Tetrahedron Letters p. 5327 - 5330 (1995)

Update date:2022-07-29

Topics:

Authors:

Bauta, William

Booth, John

Bos, Mary Ellen

DeLuca, Mark

Diorazio, Louis

Donohoe, Timothy

Magnus, Nicholas

Magnus, Philip

Mendoza, Jose

Pye, Philip

Tarrant, James

Thom, Stephen

Ujjainwalla, Feroze

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)01083-T

The BC-rings of taxol can be synthesized using an intramolecular [5+2]- pyrylium ylide-alkene cyclization, followed by gem-methylcyclopropanation and reductive cleavage of the internal cyclopropane bond.

Full text of DOI:10.1016/0040-4039(95)01083-T

Products guided by the article

Product name:(S)-1-Furan-2-yl-3-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-(4-methyl-pent-4-enyl)-propane-1,3-dione

Cas No:184867-89-8

R&D Labs maybe for 184867-89-8

Changsha Easchem Co.,Limited

website:http://www.easchem.com

Contact:+86-731-89722861 89722891

Address:2/F-4/Bld Colorful Palace, No.605 Changsha Ave, Yuhua Area Changsha Hunan China.
Fujian Wanke Pharmaceutical Co., LTD.

Contact:+86-598-5026002

Address:Economic development zone,jiangle county
Shangyu Sanhechemicals Co.,LTD.

Contact:86-0571-56696839

Address:Num.2952,Nanhuan Road,Binjiang District,Hangzhou,China
Deltachem(QingDao)Co.,Ltd.

Contact:+8618766299236

Address:ROOM808, BUILDING2,NO.230 SHEN ZHEN ROAD, LAOSHAN DISTRICT
Shanghai Kangxin Chemical Co., Ltd

Contact:+86 21 60717227

Address:118,Ganbai Village,Waigang Town,Jiading District,Shanghai

Relevant to this article

Doi:10.1021/jo01254a051
(1969)
Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acid

Doi:10.1016/S0960-894X(97)00435-6
(1997)
Increased Lipophilicity of Halogenated Ruthenium(II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro when Used as Photosensitizers for Photodynamic Therapy

Doi:10.1002/cbic.202000289
(2020)
Efficient synthesis of 1-amino-2-naphthalenecarboxylic acid derivatives via a sequential Michael addition/enolate-nitrile coupling route and its application to facile preparation of 9-amino analogues of arylnaphthofuranone lignans

Doi:10.1021/jo961744r
(1997)
Doi:10.1016/S0020-1693(00)93319-X
(1970)
Revisit of the leaving group (LG)/halogen exchange in 1,2-dimesityl-2-phenylvinyl-LG systems: A caveat about 'mistaken identity' by X-ray diffraction

Doi:10.1002/poc.430
(2001)

Article Doi