New strategy for the synthesis of the taxane diterpenes: Formation of the BC-rings of taxol via a [5+2]-pyrylium ylide-alkene cyclization, ring expansion strategy

DOI: 10.1016/0040-4039(95)01083-T

Source and publish data:

Tetrahedron Letters p. 5327 - 5330 (1995)

Update date:2022-07-29

Topics:

Authors:

Bauta, William

Booth, John

Bos, Mary Ellen

DeLuca, Mark

Diorazio, Louis

Donohoe, Timothy

Magnus, Nicholas

Magnus, Philip

Mendoza, Jose

Pye, Philip

Tarrant, James

Thom, Stephen

Ujjainwalla, Feroze

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Article abstract of DOI:10.1016/0040-4039(95)01083-T

The BC-rings of taxol can be synthesized using an intramolecular [5+2]- pyrylium ylide-alkene cyclization, followed by gem-methylcyclopropanation and reductive cleavage of the internal cyclopropane bond.

Full text of DOI:10.1016/0040-4039(95)01083-T

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