Bioorganic and Medicinal Chemistry Letters p. 2617 - 2622 (1997)
Update date:2022-09-26
Topics:
Shishido, Kozo
Haruna, Shigenori
Yamamura, Chisato
Iitsuka, Hiromi
Nemoto, Hisao
Shinohara, Yasuo
Shibuya, Masayuki
The design and synthesis of enantiomerically enriched hybrid molecules, 1a-c and 2a-c, have been accomplished by employing the lipase-mediated asymmetric acetylation of prochiral diol 9 as the key step. Evaluation of their DNA-cleaving activity has revealed the unnatural type of enantiomer 2a-c to be more potent than 1a-c with natural configuration.
View MoreContact:+86 755 26588093
Address:No.9 Linkong West Street, Hengdian Street, Huangpi District, Wuhan City, China.
Jiangsu Zenji Pharmaceuticals LTD
Contact:+86-025-83172562; +1-224-888-1133(USA)
Address:No.5 Xinmofan Road
Contact:+86-21-56338808
Address:799 Dunhuang Road, Putuo
Contact:886 2 2541 0022
Address:8 Fl., No. 11, Sec. 1, Chung Shan North Rd., Taipei, Taiwan R.O.C.
Suzhou Chiral Pharmaceuticals Co., Ltd.
Contact:86-0512-63197058
Address:Building A, No. 2358, Chang'an Road, Wujiang Science Park
Doi:10.1016/s0020-1693(96)05325-x
(1996)Doi:10.1016/0968-0896(96)00185-X
(1996)Doi:10.1021/ja00996a029
(1967)Doi:10.1016/j.tet.2012.11.064
(2013)Doi:10.1016/j.tet.2012.11.050
(2013)Doi:10.1021/jo00040a013
(1992)
