Bioorganic and Medicinal Chemistry Letters p. 2617 - 2622 (1997)
Update date:2022-09-26
Topics:
Shishido, Kozo
Haruna, Shigenori
Yamamura, Chisato
Iitsuka, Hiromi
Nemoto, Hisao
Shinohara, Yasuo
Shibuya, Masayuki
The design and synthesis of enantiomerically enriched hybrid molecules, 1a-c and 2a-c, have been accomplished by employing the lipase-mediated asymmetric acetylation of prochiral diol 9 as the key step. Evaluation of their DNA-cleaving activity has revealed the unnatural type of enantiomer 2a-c to be more potent than 1a-c with natural configuration.
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