Bioorganic and Medicinal Chemistry Letters p. 1759 - 1764 (1996)
Update date:2022-08-04
Topics:
Jagdmann Jr., G. Erik
Defauw, Jean M.
Lampe, John W.
Darges, James W.
Kalter, Kiyomi
Balanol ((-)-1) is a potent protein kinase inhibitory natural product isolated from the fungus Verticillium balanoides. The lack of cellular activity and protein kinase C selectivity in balanol has prompted a search for analogs that incorporate these properties. This paper describes the synthesis and biological activity of such compounds with substitution similar to balanol, but with a single atom bridge in place of the carboxamide moiety.
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