Solid phase synthesis of oligodeoxynucleoside phosphorodithioates by a phosphotriester method using a chemoselective coupling reagent

DOI: 10.1016/0040-4039(96)01820-5

Source and publish data:

Tetrahedron Letters p. 8041 - 8044 (1996)

Update date:2022-08-04

Topics:

Authors:

Kehler, Jan

Pueschl, Ask

Dahl, Otto

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Article abstract of DOI:10.1016/0040-4039(96)01820-5

A phosphotriester method has been developed for solid phase synthesis of oligodeoxynucleoside phosphorodithioates. Couplings are performed by chemoselective oxygen activation of protected nucleoside dithiophosphate anions 1, 7, 8, 9 with 4-nitro-6-trifluo

Full text of DOI:10.1016/0040-4039(96)01820-5

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