Application of the chemo- and enantioselective cyclopropanation of polyenes to the total synthesis of (+)-bicyclohumulenone

Article abstract of DOI:10.1016/S0040-4020(97)01014-4

The chemo- and enantioselective cyclopropanation of a monoprotected bis(allylic alcohol) using a chiral dioxaborolane- derived ligand and Zn(CH₂I)₂ was used as a key step in the total synthesis of (+)-bicyclohumulenone. The synthesis