Syntheses and antifilarial profile of 5-amino and 5,8-diamino-isoquinoline derivatives: A new class of antifilarial agents

DOI: 10.1016/S0960-894X(96)00458-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2623 - 2628 (1996)

Update date:2022-08-03

Topics:

Authors:

Srivastava, Sanjay K.

Chauhan Chauhan

Agarwal Agarwal

Bhaduri Bhaduri

Singh Singh

Fatma, Nigar

Chatterjee

Bose, Chhanda

Srivastava

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Article abstract of DOI:10.1016/S0960-894X(96)00458-1

The syntheses of 5-amino (4-12,15) and 5,8-diamino (16-17) isoquinoline derivatives, their antifilarial activity and their effect on metabolic activities of filariids are delineated. Some of the screened compounds have shown promising filaricidal response against Acanthocheilonema viteae in rodents.

Full text of DOI:10.1016/S0960-894X(96)00458-1

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