Syntheses and antifilarial profile of 5-amino and 5,8-diamino-isoquinoline derivatives: A new class of antifilarial agents

Article abstract of DOI:10.1016/S0960-894X(96)00458-1

The syntheses of 5-amino (4-12,15) and 5,8-diamino (16-17) isoquinoline derivatives, their antifilarial activity and their effect on metabolic activities of filariids are delineated. Some of the screened compounds have shown promising filaricidal response against Acanthocheilonema viteae in rodents.