Enantioselective synthesis of (+)-goniodiol and of its naturally occurring acetylated analogs

Article abstract of DOI:10.1016/0040-4020(96)00918-0

A novel route to enantioenriched (+)-goniodiol and its natural acetylated derivatives, potent cytotoxic compounds, is described. The main features of this synthesis are transfer of the asymmetric information of the scalemic allenic alcohol 5 to the α- and β- carbons through highly diastercoselective reactions and introduction of the α,β-unsaturated lactone moiety by the Ghosez' methodology.