Synthesis of high-specific activity tritium and optically pure [14C]CP 101,606. Enantioselective crystallization of a radiochemically racemic mixture.

Article abstract of DOI:10.1002/(SICI)1099-1344(199712)39:12<973::AID-JLCR40>3.0.CO;2-O

The syntheses of racemic, high-specific activity tritium and optically pure, carbon-14 labelled CP-101,606 is described. The tritium labelled material was prepared at 35.6 Ci/mmol by hydrogenolysis of the dibromo analog 5. In the carbon-14 synthesis, the